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$600.00 (Negotiable)

Veterniary Drug Cat Fip Antiviral API Chemical Intermediate GS-441524

  • Veterniary Drug Cat Fip Antiviral API Chemical Intermediate GS-441524
  • Veterniary Drug Cat Fip Antiviral API Chemical Intermediate GS-441524
  • Veterniary Drug Cat Fip Antiviral API Chemical Intermediate GS-441524
  • Veterniary Drug Cat Fip Antiviral API Chemical Intermediate GS-441524
  • Veterniary Drug Cat Fip Antiviral API Chemical Intermediate GS-441524
Description
Price : $600.00 (Negotiable)
Date : January 6, 2022
Type of animal : Cat
Location :Room 1818,Future Time Business Buil

Product Name:GS-441524

CAS:1191237-69-0

MF:C12H13N5O4

MW:291.26

EINECS:200-001-8

Description

GS-441524 is a nucleoside analogue that terminates the RNA chain of viral RNA-dependent RNA polymerase.

GS-441524 was developed by Gilead Sciences, Inc as part of their research into human RNA virus disease such as Ebola.

GS-441524 is a small molecule that exhibits potent antiviral activity against a number of RNA viruses, including the zoonotic severe acute respiratory syndrome (SARS) coronavirus ( Cho et al., 2012). A phosphoramidate prodrug of GS-441524 (GS-5734) has been previously shown to inhibit the replication of several taxonomically diverse RNA viruses such as Middle East respiratory syndrome virus, Ebola virus, Lassa fever virus, Junin virus and respiratory syncytial virus, while having low cytotoxicity in a wide-range of cell lines ( Sheahan et al., 2017 ). GS-5734 has also been shown to protect rhesus monkeys from experimental Ebola virus infection.

Feline infectious peritonitis (FIP) is a devastating and almost always fatal cat disease that originates from a mutation in the common feline coronavirus (FECV), which infects 40-80% of cats worldwide. GS-441524, also known as GS-5734, is an effective inhibitor of feline infectious peritonitis (FIP) virus. GS-441524 has a strong inhibitory effect on feline infectious peritonitis (FIP) virus. GS-441524 is a molecular precursor of nucleoside triphosphate molecules with pharmacological activity. These analogs can be used as alternative substrates and RNA chain terminators for viral RNA-dependent RNA polymerase. The non-toxic concentration of GS-441524 in feline cells is as high as 100, which effectively inhibits FIPV replication in CRFK cell culture and naturally infected cat peritoneal macrophages with a concentration as low as 1.

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